The Rose and Mackay Textbook of Autoimmune Diseases Seventh Edition is a comprehensive reference that emphasizes the “3 P’s” of 21st Century medicine: precision, prediction, and prevention. Topics cover the modern systems approach to biology that involves large amounts of personalized, ongoing physiologic data (“omics”) coupled with advanced methods of analysis, new tests of genetic engineering, such as CRISPR, auto inflammatory diseases, autoimmune responses to tumor immunotherapy, and information on normal immune response and disorders. Each of the major autoimmune disorders is discussed by researchers and clinical investigators experienced in dealing with patients.

This new edition continues its success with 75% of the content revised, updated, or completely new. This edition is a valuable resource to clinicians involved in the diagnosis and treatment of autoimmune disease, as well as to scientists who want to follow developments in the field.

• Provides new research on autoimmune diseases, their diagnosis, prevention, and therapy
• Covers a complete range of all common, rare and new autoimmune diseases, including cancer and COVID
• Extensively revised with 75% new material based on autoimmunity, developments in the different diagnosis and therapies for these autoimmune diseases, and a completely updated description of the different diseases
• Supplemented with a website that hosts a Podcast per chapter

۱ Development of adaptive immune cells
۲ Revision to the origins of the mononuclear phagocyte
۳ Tolerance and activation of peripheral B and T cells
۴ Genetic alterations leading to autoimmunity
۵ Microbiome in autoimmunity
۶ Metabolic control of pathogenesis in autoimmune diseases
۷ Triggers for autoimmunity
۸ Organ damage in autoimmune disease
۹ Therapeutic strategies for treating autoimmune disease
۱۰ Systemic lupus erythematosus
۱۱ Systemic sclerosis (scleroderma)
۱۲ Antiphospholipid syndrome
۱۳ Sjögren’s disease
۱۴ Rheumatoid arthritis
۱۵ Juvenile idiopathic arthritis
۱۶ Spondyloarthritis
۱۷ Autoimmune myositis
۱۸ Relapsing polychondritis
۱۹ IgG4-related disease
۲۰ Necrotizing arteritis and small-vessel vasculitis
۲۱ Large and medium vessel vasculitides
۲۲ Autoimmune diseases of the kidney
۲۳ Autoimmune hemolytic anemia
۲۴ Acquired aplastic anemia
۲۵ Autoimmune clotting dysfunction
۲۶ Immune thrombocytopenia
۲۷ Thrombotic thrombocytopenic purpura
۲۸ Macrophage activation syndrome
۲۹ Autoimmune leukopenia
۳۰ Autoimmune thyroid diseases
۳۱ Autoimmune (Type 1) diabetes
۳۲ Adrenalitis
۳۳ Autoimmune polyendocrine syndromes
۳۴ Autoimmune gastritis and pernicious anemia
۳۵ Autoimmune hypophysitis
۳۶ Autoimmune primary ovarian insufficiency
۳۷ Endometriosis as an autoimmune disease
۳۸ Primary hypoparathyroidism or non-surgical hypoparathyroidism
۳۹ Celiac disease
۴۰ Inflammatory bowel disease
۴۱ Autoimmune gastrointestinal dysmotility
۴۲ Autoimmune pancreatitis
۴۳ Primary sclerosing cholangitis and IgG4-associated cholangitis
۴۴ Autoimmune hepatitis
۴۵ Primary biliary cholangitis
۴۶ Rheumatic fever and rheumatic heart disease
۴۷ Myocarditis and dilated cardiomyopathy
۴۸ Autoimmune interstitial lung disease
۴۹ Sarcoidosis—a multisystemic disease
۵۰ Autoimmune inner ear disease
۵۱ Meniere disease
۵۲ Autoinflammatory inner ear disease (AID)
۵۳ Episcleritis and scleritis
۵۴ Anterior uveitis
۵۵ Pediatric uveitis
۵۶ Intermediate uveitis
۵۷ White dot syndromes
۵۸ Panuveitis
۵۹ Regional corticosteroid therapy for noninfectious uveitis
۶۰ Autoimmune bullous skin disorders
۶۱ Pemphigus
۶۲ Bullous pemphigoid
۶۳ Dermatitis herpetiformis
۶۴ Cutaneous lupus erythematosus
۶۵ Vasculitis from the dermatologist’s perspective
۶۶ Psoriasis
۶۷ Cutaneous graft-versus-host disease
۶۸ Vitiligo
۶۹ Alopecia areata
۷۰ Chronic spontaneous urticaria
۷۱ Skin involvement in other autoimmune diseases
۷۲ Multiple sclerosis
۷۳ Neuromyelitis optica spectrum disorder and other central nervous system inflammatory diseases
۷۴ Pediatric multiple sclerosis and acute disseminated encephalomyelitis
۷۵ Paraneoplastic neurological syndromes
۷۶ Autoimmune encephalitis
۷۷ Central nervous system manifestations of systemic autoimmune diseases
۷۸ Peripheral neuropathies
۷۹ Autoimmune disorders of the neuromuscular junction
۸۰ The autoimmune myopathies