Offered in print, online, and downloadable formats, this updated edition of Stroke: Pathophysiology, Diagnosis, and Management deliversconvenient access to the latest research findings and management approaches for cerebrovascular disease. Picking up from where J. P. Mohr and colleagues left off, a new team of editors – Drs. Grotta, Albers, Broderick, Kasner, Lo, Mendelow, Sacco, and Wong – head the sixth edition of this classic text, which is authored by the world’s foremost stroke experts.

• Comprehensive, expert clinical guidance enables you to recognize the clinical manifestations of stroke, use the latest laboratory and imaging studies to arrive at a diagnosis, and generate an effective medical and surgical treatment plan.
• Abundant full-color CT images and pathology slides help you make efficient and accurate diagnoses.

• Data from late-breaking endovascular trials equips you with recent findings.
• Includes comprehensive coverage of advances in molecular biology of cell death; risk factors and prevention; advances in diagnostics and stroke imaging; and therapeutic options, including a thorough review of thrombolytic agents and emerging data for endovascular therapy.
• Features brand-new chapters on Intracellular Signaling: Mediators and Protective Responses; The Neurovascular Unit and Responses to Ischemia; Mechanisms of Cerebral Hemorrhage; Stroke Related to Surgery and Other Procedures; Cryptogenic Stroke; and Interventions to Improve Recovery after Stroke.
• Highlights new information on genetic risk factors; primary prevention of stroke; infectious diseases and stroke; recovery interventions such as robotics, brain stimulation, and telerehabilitation; and trial design.
• Details advances in diagnostic tests, such as ultrasound, computed tomography (including CT angiography and CT perfusion), MRI (including MR perfusion techniques), and angiography.
• Includes extracted and highlighted evidence levels.
• Expert Consult eBook version included with print purchase. This enhanced eBook experience allows you to search all of the text, figures, and references on a variety of devices. The content can also be downloaded totablets and smart phones for offline use.

Combat stroke with the most comprehensive and updated multimedia resource on the pathophysiology, diagnosis, and management of stroke from leaders in the field

Review

“Authoritative, eminently readable, and current.”-Journal of Neurosurgery

“[F]or depth of coverage of individual subjects and as a reference for cerebrovascular diseases, [Stroke] has become the standard.”-Annals of Internal Medicine

“Should be part of the libraries of all [those] who deal with cerebrovascular disease.” –JAMA

“Updating such a big reference work is a huge task, and by and large the editors have succeeded in their task. They have assembled many very distinguished authors and put together a pretty comprehensive reference work.” -Journal of Neurology Neurosurgery and Psychiatry

Reviews of previous edition. “There are sections on pathophysiology, epidemiology, clinical manifestation and individual sections dealing with specific pathological conditions explaining each in great depth. In addition, it has extensive sections devoted to therapy including medical, interventional and surgical. All this makes the book a one-stop-shop for stroke. As a result, it is a work that will prove valuable to a wide range of clinicians involved with providing stroke services, including stroke physicians, acute care physicians, researchers, public health physicians and those involved with rehabilitation medicine…In comparison to the previous editions, the book has definite a advantages in the form of picture quality and web access. It is excellent value for the price as a reference book for stroke, not radiology specific. The book would find its place in a departmental radiology library. Overall, an excellent, up-to-date reference volume.” RAD, May 2012

About the Author

Professor of Neurology, Chairman, Department of Neurology, University of Texas Medical School at Houston; Director, Stroke Program, Memorial Hermann – Texas Medical Center, Houston, TX

Contents

I Pathophysiology

۱ Vascular Biology and Atherosclerosis of Cerebral Vessels
۲ Mechanisms of Thrombosis and Thrombolysis
۳ Cerebral Blood Flow and Metabolism:
۴ Histopathology of Brain Tissue Response to Stroke and Injury
۵ Molecular and Cellular Mechanisms of Ischemia-Induced Neuronal Death
۶ Intracellular Signaling:
۷ The Neurovascular Unit and Responses to Ischemia
۸ Mechanisms of Cerebral Hemorrhage
۹ White Matter Pathophysiology
۱۰ Inflammation and Immune Response
۱۱ Mechanisms of Plasticity, Remodeling and Recovery
۱۲ Genetics and Vascular Biology of Angiogenesis and Vascular Malformations

II Epidemiology and Risk Factors

۱۳ Global Burden of Stroke
۱۴ Stroke Disparities
۱۵ Modifiable Risk Factors and Determinants of Stroke
۱۶ Prognosis after Stroke
۱۷ Vascular Dementia and Cognitive Impairment
۱۸ Genetic Basis of Stroke Occurence, Prevention and Outcome
۱۹ Preventing a First Stroke

III Clinical Manifestations

۲۰ Classification of Ischemic Stroke
۲۱ Clinical Scales to Assess Patients with Stroke
۲۲ Carotid Artery Disease
۲۳ Anterior Cerebral Artery Disease
۲۴ Middle Cerebral Artery Disease
۲۵ Posterior Cerebral Artery Disease
۲۶ Vertebrobasilar Disease
۲۷ Lacunar Syndromes, Lacunar Infarcts, and Cerebral Small-vessel Disease
۲۸ Intracerebral Hemorrhage
۲۹ Aneurysmal Subarachnoid Hemorrhage
۳۰ Arteriovenous Malformations and Other Vascular Anomalies
۳۱ Stroke and Other Vascular Syndromes of the Spinal Cord

IV Specific Conditions and Stroke

۳۲ Cardiac Diseases
۳۳ Atherosclerotic Disease of the Proximal Aorta
۳۴ Stroke Related to Surgery and Other Procedures
۳۵ Arterial Dissections and Fibromuscular Dysplasia
۳۶ Collagen Vascular and Infectious Diseases
۳۷ Reversible Cerebral Vasoconstriction Syndromes
۳۸ Hypertensive Encephalopathy
۳۹ Stroke and Substance Abuse
۴۰ Moyamoya Disease
۴۱ CADASIL:
۴۲ Hematologic Disorders and Stroke
۴۳ Migraine and Stroke
۴۴ Cryptogenic Stroke
۴۵ Cerebral Venous Thrombosis

V Diagnostic Studies

۴۶ Ultrasonography
۴۷ Computed Tomography-based Evaluation of Cerebrovascular Disease
۴۸ Magnetic Resonance Imaging of Cerebrovascular Diseases
۴۹ Cerebral Angiography

VI Therapy

A Medical Therapy
B Interventional Therapy
C Surgical Therapy