Understanding how the brain works and developing effective therapeutics are important in advancing neuroscience and improving clinical patient care. This book covers state-of-the-art research and development in optical technologies and applications for brain mapping and therapeutics. It provides a comprehensive overview of various methods developed using light, both microscopic and macroscopic techniques. Recent developments in minimally-invasive endoscopic imaging of deep brain structure and function, as well as light-based therapy are also reviewed.

Features

• Covers optical methods for imaging, sensing, and manipulating brain structure and function, as well as multiphoton microscopy, functional brain mapping, image-guided neurosurgery, and optogenetics
• Focuses on disease diagnostics and therapeutics in addition to current methodologies
• Structured around literature-based studies
• Discusses optical imaging in the context of neurosciences

About the Author

Contents

Chapter 1: History of Brain Mapping and Neurophotonics: From Technological Discoveries to Brain Initiatives
Chapter 2: Pain Assessment Using Near-Infrared Spectroscopy
Chapter 3: Application of Functional Near-Infrared Spectroscopy in Brain Mapping
Chapter 4: Therapeutic Monitoring of Children with Attention Deficit Hyperactivity Disorder Using fNIRS Assessment
Chapter 5: Functional Near-Infrared Spectroscopy: In Search of the Fast Optical Signal
Chapter 6: Voltage-Sensitive Dye and Intrinsic Signal Optical Imaging: Advantages and Disadvantages for Functional Brain Mapping
Chapter 7: Optical Techniques to Study Drug-Induced Neurovascular and Cellular Changes In Vivo
Chapter 8: Three-Dimensional Optical Coherence Microscopy Angiography and Mapping of Angio-Architecture in the Central Nervous System
Chapter 9: Doppler Optical Coherence Tomography and Its Application in Measurement of Cerebral Blood Flow
Chapter 10: Brain Imaging and Mapping with Multi-Contrast Optical Coherence Tomography
Chapter 11: Advanced Optical Imaging in the Study of Acute and Chronic Response to Implanted Neural Interfaces
Chapter 12: Photoacoustic Neuroimaging
Chapter 13: Perfusion Brain Mapping in the Treatment of Acute Stroke
Chapter 14: Mapping the Injured Brain: Structure and Function Following Traumatic Brain Injury
Chapter 15: UV-Based Imaging Technologies for Intraoperative Brain Mapping
Chapter 16: Visible Light Optical Imaging and Spectroscopy during Neurosurgery
Chapter 17: Intraoperative Infrared Optical Imaging in Neurosurgery
Chapter 18: Autofluorescence-Guided Resection of Intracranial Tumor: Pastr Present,, and Future
Chapter 19: Spectro-Temporal Autofluorescence Contrast-Based Imaging for Brain Tumor Margin Detection and Biobanking
Chapter 20: Optical Coherence Tomography and Quantitative Optical Imaging of Brain Cancer
Chapter 21: Intraoperative Optical Guidance for Neurosurgery
Chapter 22: Impact of Retinal Stimulation on Neuromodulation
Chapter 23: FUS-Mediated Image-Guided Neuromodulation of the Brain
Chapter 24: Advances in Portable Neuroimaging and Their Effect on Novel Therapies
Chapter 25: The Deep Brain Connectome
Chapter 26: Neurovascular Photonics
Chapter 27: Neurophotonics for Peripheral Nerves
Chapter 28: EEG Biomarkers in Depression
Chapter 29: fMRI as a Biomarker in Neuroimaging
Chapter 30: Single-Neuron Recordings from Depth Electrodes with Embedded Microwires in Epilepsy Patients: Techniques and Examples