Homeostatic Control of Brain Function offers a broad view of brain health and diverse perspectives for potential treatments, targeting key areas such as mitochondria, the immune system, epigenetic changes, and regulatory molecules such as ions, neuropeptides, and neuromodulators. Loss of homeostasis becomes expressed as a diverse array of neurological disorders.

Each disorder has multiple comorbidities – with some crossing over several conditions – and often disease-specific treatments remain elusive. When current pharmacological therapies result in ineffective and inadequate outcomes, therapies to restore and maintain homeostatic functions can help improve brain health, no matter the diagnosis. Employing homeostatic therapies may lead to future cures or treatments that address multiple comorbidities. In an age where brain diseases such as Alzheimer’s or Parkinson’s are ever present, the incorporation of homeostatic techniques could successfully promote better overall brain health.

Key Features include

· A focus on the homeostatic controls that significantly depend on the way one lives, eats, and drinks.
· Highlights from emerging research in non-pharmaceutical therapies including botanical medications, meditation, diet, and exercise.
· Incorporation of homeostatic therapies into existing basic and clinical research paradigms.
· Extensive scientific basic and clinical research ranging from molecules to disorders.
· Emerging practical information for improving homeostasis.
· Examples of homeostatic therapies in preventing and delaying dysfunction.

Both editors, Detlev Boison and Susan Masino, bring their unique expertise in homeostatic research to the overall scope of this work. This book is accessible to all with an interest in brain health; scientist, clinician, student, and lay reader alike.

Review

Contents

۱. Microdynamics of Water and Ion Homeostasis in the Brain: Role of Aquaporins and Ion Channels of Astroglial Cells
۲. Homeostatic Control of Adenosine Levels and Functions in the Brain
۳. Glutamate Homeostasis as a Regulator of Neuretransmitter Recycling and Synaptic Function
۴. Homeostasis of Neuronal Excitability Via Synaptic and Intrinsic Inhibitory Mechanisms
۵. Role of Astrocytes in Sleep and Epilepsy
۶. Astrocyte-Neuron Interactions
۷. Homeostatic Synaptic Scaling at Central Synapses
۸. Homeostatic Role of Heterosynaptic Plasticity
۹. The Blood-Brain Barrier
۱۰. Inflammation and Immunomodulation in Epilepsy and Its Comorbidities
۱۱. Neuroplasticity
۱۲. Epigenetics
۱۳. Adult Neural Stem Cells and Brain Homeostasis
۱۴. Systems (Network) Pharmacology for Brain Functionality Restoration
۱۵. Ketogenic Diets for Neurological Disorders
۱۶. Dietary Manipulations
۱۷. Exercise
۱۸. Sleep
۱۹. Botanicals
۲۰. The Role of Acupuncture in Nociception Homeostasis
۲۱. Meditation
۲۲. Neurotrophic Regulation in Neurorestoration of the Brain
۲۳. Epilepsy
۲۴. Traumatic Brain Injury
۲۵. Adenosine and Alzheimer’s Disease: A Possible Epigenetic Link
۲۶. Brain Homeostasis and Parkinson’s Disease
۲۷. Brain Homeostasis and Addiction
۲۸. Anxiety and Stress Disorders
۲۹. Malignant Brain Cancer Management with Metabolic Therapy
۳۰. Obesity and Diabetes: Naturer Nurture, and Beyond
۳۱. Autism Spectrum Disorder and Homeostasis