Succinct yet comprehensive, Aminoff’s Diagnosis of Neuromuscular Disorders, 4th Edition, provides expert information and guidance on the clinical, electrodiagnostic, and imaging aspects of neuromuscular disorders. Fully updated, it reflects important advances in the field, including an improved understanding of the molecular and genetic basis of neuromuscular disease, an expanded use of next-generation genetic testing, refinements in electrodiagnosis, and the use of ultrasound imaging techniques to evaluate the peripheral nervous system. In-depth discussions of disease states, as well as the evidence supporting the use of electrodiagnostic and imaging techniques, moves this reference from simply answering the question “How?” to also answering “Why?”

• Describes the range of clinical manifestations of individual neuromuscular diseases; the power and limitations of electrodiagnostic techniques as they relate to neuromuscular disorders; the place of genetic studies in the diagnosis and prognostication of these diseases; and the scope and utility of newer imaging procedures in detecting and localizing the underlying pathologic process.
• Reviews neuromuscular physiology and the pathology of major diseases.
• Provides a readable, well-illustrated synthesis of clinical and investigative techniques in diagnosing neuromuscular diseases, with concise guidance on how to conduct clinical, electrodiagnostic, and ultrasound evaluations and the findings in various disease states.
• Covers a wide variety of electrodiagnostic and ultrasound procedures, including techniques for evaluating different individual nerves.
• Features video clips of waveforms and of ultrasound images to illustrate key concepts.
• An ideal resource for neuromuscular specialists, clinical neurologists, physiatrists, rehabilitation specialists, clinical neurophysiologists, and electromyographers, as well as trainees and those preparing for board certification in neurology, PM&R, neuromuscular medicine, clinical neurophysiology, and electrodiagnostic medicine.

Review

Aminoff’s Diagnosis of Neuromuscular Disorders An up-to-date review of the clinical, electrodiagnostic, and imaging aspects of neuromuscular medicine

About the Author

Dr. Michael J. Aminoff, Distinguished Professor Emeritus in neurology at the University of California San Francisco, is an internationally recognized neurologist, clinical investigator, and author.

Contents

۱. Diagnosis of Neuromuscular Disorders۲. Biopsies and Neuromuscular Disease۳. Neuromuscular Imaging۴. Genetic Evaluation of Neuromuscular Disorders۵. Aspects of Nerve and Muscle Physiology۶. Properties and Functional Organization of Motor Units۷. Electrodiagnostic Apparatus۸. General Aspects of Needle Electromyography۹. Clinical Aspects of Needle Electromyography۱۰. Nerve Conduction Studies: Basic Principles and Pathologic Correlations۱۱. Quantitative and Related Techniques of Electromyography and Electroneurography۱۲. Other Neurophysiologic Techniques for the Evaluation of Neuromuscular Disorders۱۳. Evaluation of the Autonomic Nervous System۱۴. Myopathic Disorders and Myalgia۱۵. Muscle Channelopathies۱۶. Motor Neuron Disorders۱۷. Muscle Fiber and Motor Unit Hyperactivity States۱۸. Polyneuropathy and Mononeuropathy Multiplex۱۹. Root and Plexus Lesions۲۰. Neuromuscular Transmission and Its Disorders۲۱. Traumatic Neuropathy and Surgical Interventions۲۲. Median Neuropathies۲۳. Ulnar Neuropathies۲۴. Radial Neuropathies۲۵. Disturbances of Other Nerves in the Upper Extremities۲۶. Fibular (Peroneal) Neuropathies۲۷. Tibial and Sural Neuropathies۲۸. Sciatic Neuropathies۲۹. Disturbances of Other Nerves in the Lower Extremities۳۰. Facial Neuropathies۳۱. Disturbances of Other Cranial Nerves and the Phrenic Nerve۳۲. Electrophysiologic Evaluation of Selected Aspects of the Central Nervous System

Video Contents

۱. Ultrasound of fasciculations in abductor hallucis with B- and M-mode imaging۲. Ultrasound of fibrillations and a single fasciculation potential in thenar muscles۳. Ultrasound of the palmar cutaneous branch of the median nerve and palmar fascia۴. Ultrasound of the diaphragm and of lung movement, imaged between ribs 7 and 8۵. Differences in evoked foot and hand movement between single nerve stimulation and excess stimulus intensity co-activating an adjacent nerve۶. In vitro time-lapse photography showing movement of a Schwann cell along a tubule with endothelial cell lining۷. In vitro time-lapse photography showing an axon reinnervating a neuromuscular junction۸. The appearance of rippling muscle disease in the thigh of an affected patient۹. The appearance of myokymia in a patient’s deltoid muscle, 8 years after radiation therapy۱۰. The appearance of ptosis and ocular paresis and their improvement following intravenous edrophonium۱۱. Axial ultrasound imaging of the median nerve from the antecubital fossa to the distal one-third of the forearm۱۲. Axial ultrasound imaging of the median nerve from the forearm to the palm۱۳. Axial ultrasound imaging of the median nerve in the carpal tunnel at rest and with flexion and extension of the fingers and wrist۱۴. Sagittal ultrasound imaging of the median nerve in the carpal tunnel at rest and with flexion and extension of the fingers and wrist۱۵. Axial ultrasound imaging of a persistent median artery and veins from wrist to antecubital fossa, showing proximal variant anatomy as well۱۶. Axial ultrasound imaging of the ulnar nerve from axilla to wrist using different instruments۱۷. Axial ultrasound imaging of intramuscular branches of the ulnar nerve in flexor carpi ulnaris۱۸. Axial ultrasound imaging of the ulnar nerve in the distal forearm showing the takeoff of the ulnar palmar cutaneous branch۱۹. Axial ultrasound imaging of the ulnar nerve in the distal forearm showing the branching of the dorsal ulnar cutaneous nerve and artery۲۰. Axial ultrasound imaging of the ulnar nerve at the elbow subluxing and then dislocating with elbow flexion۲۱. Axial ultrasound imaging of the fibular (peroneal) nerve and its branches from the distal thigh to the flexor retinaculum of the foot۲۲. Axial ultrasound imaging of the sural nerve and its communication with the fibular and tibial nerves۲۳. Axial ultrasound imaging of tibialis anterior, extensor digitorum longus, and tibialis posterior muscles with dorsiflexion and inversion of the foot۲۴. Axial ultrasound images of the vagus nerve from the base of the skull to the thyroid۲۵. Axial ultrasound images of the spinal accessory nerve coursing in the posterior triangle of the neck from behind the sternocleidomastoid to below the trapezius۲۶. Axial imaging of the tongue and related muscles from below the jaw at rest and during swallowing in a healthy individual and a patient with marked chorea۲۷. Long axis (sagittal) ultrasound imaging of the injection of botulinum toxin into the sternocleidomastoid muscle, as well as electromyographic tracings before and weeks after an injection

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