This volume discusses a variety of Preclinical MRI: Methods and Protocols to help technicians and researchers conduct studies in their respective fields. This book is organized into 7 parts: Part 1 covers the basics of MRI physics, relaxation, image contrast, and main acquisition sequences; Part 2 describes methodologies for diffusion, perfusion, and functional imaging; Part 3 looks at in vivo spectroscopy; Part 4 explores special MRI techniques that are less known in the field; Parts 5 and 6 discuss MRIs and MRSs in animal models of disease and the applications used to study them, and Part 7 looks at anesthesia and advanced contrast agents. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Comprehensive and thorough, Preclinical MRI: Methods and Protocols is a valuable resource for researchers interested in expanding their knowledge in this developing field.

Contents

۱. Introduction to MRI Physics
۲. Basic Pulse Sequences in Magnetic Resonance Imaging
۳. Dynamic Susceptibility Contrast MRI in Small Animals
۴. Preclinical Arterial Spin Labeling Measurement of Cerebral Blood Flow
۵. Dynamic Contrast-Enhanced MRI
۶. Diffusion-Weighted Magnetic Resonance Imaging
۷. Diffusion Tensor Imaging (DTI)
۸. Mapping Functional Connectivity in the Rodent Brain Using Electric-Stimulation fMRI
۹. Functional Diffusion Magnetic Resonance Imaging
۱۰. In Vivo 1H Magnetic Resonance Spectroscopy
۱۱. In Vivo Heteronudear Magnetic Resonance Spectroscopy
۱۲. ۱H Spectroscopic Imaging of the Rodent Brain
۱۳. Susceptibility Weighted MRI in Rodents at 9.4 T
۱۴. Biomedical 19F MRI Using Perfluorocarbons
۱۵. Rodent Abdominal Adipose Tissue Imaging by MR
۱۶. Cardiac MRI in Small Animals
۱۷. In Utero MRI of Mouse Embryos
۱۸. Oxygenation Imaging by Nuclear Magnetic Resonance Methods
۱۹. Molecular Magnetic Resonance Imaging (mMRI)
۲۰. Magnetic Resonance Spectroscopy Studies of Mouse Models of Cancer
۲۱. MRI in the Study of Animal Models of Neurodegenerative Diseases
۲۲. MRI in the Study of Animal Models of Stroke
۲۳. Assessment of Blood Brain Barrier Leakage with Gadolinium-Enhanced MRI
۲۴. In Vivo Pharmacokinetics of Magnetic Nanoparticles
۲۵. Anesthesia and Monitoring of Animals During MRI Studies
۲۶. Advanced Contrast Agents for Multimodal Biomedical Imaging Based on Nanotechnology