From bioinformatics to nanotechnology, advances in basic research ultimately drive advances in clinical care. This book provides a comprehensive summary of all current research methodologies for translational and pre-clinical studies in biomechanics and orthopedic trauma surgery. With this “roadmap” at hand, specialists and trainees will have the tools to conduct high-quality experimental research in any area of musculoskeletal science, with a solid understanding of how the findings can be applied in patient care.

Special Features:

• Utilizes the principles and methodology of modern, evidence-based medicine in pre-clinical musculoskeletal research
• Offers a comprehensive analysis of in vivo models for studying different components of the musculoskeletal system
• Demonstrates how principles of structural, functional, and numerical biomechanics can be utilized in well-defined experimental research studies – spanning topics from fracture fixation to gait analysis to bone remodeling
• Covers the role of new macroscopic CT and ultrasound imaging techniques for assessing bone and cartilage function
• Explores cutting-edge developments in cell culture research, molecular testing, and tissue engineering
• Provides practical advice, a glossary of key terminology, and hundreds of illustrations to familiarize clinicians with every aspect of designing and interpreting an effective research study

With 54 state-of-the-art chapters by orthopedic surgeons, musculoskeletal physicians, biologists, engineers, physicists, and mathematicians, Experimental Research Methods in Orthopedics and Trauma is the authoritative reference on the topic. It is essential for clinicians, basic researchers, and orthopedic surgical trainees who need to understand experimental research methodology, apply its findings, and participate fully in research activities.

Contents

۱ Evidence-Based Research
۲ Establishing a Basic Research Facility in Orthopedic Surgery
۳ Good Laboratory Practice and Quality Control
۴ How to Prepare for a Period in Research
۵ Physiological Boundary Conditions for Mechanical Testing
۶ Static, Dynamic, and Fatigue Mechanical Testing
۷ Use of Human and Animal Specimens in Biomechanical Testing
۸ Whole Bone Biomechanics
۹ Biomechanics of Trabecular and Cortical Bone
۱۰ Biomechanics of Fracture Fixation
۱۱ Biomechanical Assessment of Fracture Repair
۱۲ Biomechanics of Cartilage
۱۳ Biomechanics of Joints
۱۴ Spine Biomechanics
۱۵ Musculokeletal Dynamics
۱۶ Measurement Techniques
۱۷ Clinical Assessment of Function
۱۸ Functional Biomechanics with Cadaver Specimens
۱۹ Inverse Dynamics
۲۰ Principles of Finite Elements Analysis
۲۱ Validation of Finite Element Models
۲۲ Computational Biomechanics of Bone
۲۳ Numerical Simulation of Implants and Prosthetic Devices
۲۴ Numerical Simulation of Fracture Healing and Bone Remodelling
۲۵ Micro-Computed Tomography Imaging of Bone Tissue
۲۶ Imaging Bone
۲۷ Ultrasound Techniques for Imaging Bone
۲۸ In Vivo Scanning
۲۹ Imaging of Cartilage Function
۳۰ Histochemistry Bone and Cartilage
۳۱ Immunohistochemistry
۳۲ Molecular Imaging In Situ Hybridization
۳۳ Laser Scanning Confocal Microscopy and Laser Microdissection
۳۴ Image Analysis Histomorphometry Stereology
۳۵ Cell Culture Research
۳۶ Cartilage Explants and Organ Culture Models
۳۷ Fluid Flow and Strain in Bone
۳۸ Biomechanics of Bone Cells
۳۹ Molecular Testing
۴۰ Genetically Modified Models for Bone Repair
۴۱ General Considerations for an In Vivo Model
۴۲ Animal Models for Bone Healing
۴۳ Models for Impaired Healing
۴۴ In Vivo Models for Bone and Joint Infections
۴۵ In Vivo Models for Articular Cartilage Repair
۴۶ In Vivo Soft Tissue Models
۴۷ Scaffolds for Tissue Engineering and Materials for Repair
۴۸ Use of Growth Factors in Musculoskeletal Research
۴۹ Stem Cells for Musculoskeletal Repair
۵۰ Biological Evaluation and Testing of Medical Devices
۵۱ Study Design
۵۲ Power and Sample Size Calculation
۵۳ Nonparametric versus Parametric Tests
۵۴ How to Limit Bias in Experimental Research