This unique book describes the latest information in the fundamental understanding of the biophysics and biochemistry of articular cartilage using the state-of-the-art practices in NMR and MRI. This is the first book of its kind, written by physicists and chemists on this important tissue, whose degradation contributes to osteoarthritis and related joint diseases. Connecting the fundamental science with the clinical imaging applications, the experts Editors provide an authoritative addition to the literature.

Ideal for practising physical scientists and radiologists with an interest in the fundamental science as well as instrument manufacturers and clinical researchers working with articular cartilage.

Contents

Chapter 1 Introduction to Cartilage
Chapter 2 Osmotic Properties of Cartilage
Chapter 3 Introduction to NMR and MRI
Chapter 4 The Magic Angle Effect in NMR and MRI of Cartilage
Chapter 5 Physical Properties of Cartilage by Relaxation Anisotropy
Chapter 6 Chemical Properties of Cartilage Studied Using Charged Ions
Chapter 7 Quantification of Articular Cartilage Microstructure by the Analysis of the Diffusion Tensor
Chapter 8 Sodium and Other Exotic Methods in NMR and MRI of Cartilage
Chapter 9 Multi-Quantum Filtered NMR and MRI of Cartilage
Chapter 10 Solid-State NMR Techniques to Study the Molecular Dynamics in Cartilage
Chapter 11 Ultrashort Echo Time Imaging of Articular Cartilage
Chapter 12 Low-Field and Field-Cycling NMR and MRI of Cartilage
Chapter 13 The Influence of Specimen and Experimental Conditions on NMR and MRI of Cartilage
Chapter 14 Diffusion MRI and Poroelastic Biomechanics of Articular Cartilage
Chapter 15 Combining Multi-Modal MRI and Biomechanical Modeling to Investigate the Response of Cartilage and Chondrocytes to Mechanical Stimuli
Chapter 16 Loading-Induced Changes in Cartilage Studied by NMR and MRI
Chapter 17 The Critical Role of High Imaging Resolution in MRI of Cartilage—The MRI Microscope
Chapter 18 Multicomponent Relaxation in NMR and MRI of Cartilage
Chapter 19 Uni- and Multi-Parametric Magnetic Resonance Analysis of Cartilage
Chapter 20 Magnetic Resonance in the Assessment of Tissue Engineered Cartilage
Chapter 21 Complementary Imaging in MRI of Cartilage
Chapter 22 Quantitative MRI for Detection of Cartilage Damage
Chapter 23 Challenges for the Early Detection of Degenerative Cartilage Changes Using Magnetic Resonance Imaging In vivo in Humans
Chapter 24 Ultrahigh-Field Whole-Body MRI for Cartilage Imaging: Technical Challenges