This book explores the recent advances in the techniques and platforms used in biomarker research that have revolutionized the way we study, diagnose, and treat brain injury conditions. The contributors describe different biomarker studies pertaining to brain injury and other neurological disorders and analyze the different models and technologies used to identify these biological markers. The book includes findings from “Omics research” that have been utilized to decipher and identify such biomarkers. It discusses protein, microRNA, and altered gene profiles and reviews neurological disorders such as multiple sclerosis, Charcot-Marie-Tooth disease, and prion and Alzheimer’s disease.

Features

Contents

Section A: Biomarker Technology

۱. Neuro-proteomics and Neuro-systems Biology in the Quest of TBI Biomarker Discovery
۲. Protein Biomarkers in Traumatic Brain Injury: An Omics Approach
۳. Molecular Mechanisms and Biomarker Perspective of MicroRNAs in Traumatic Brain Injury
۴. Necrosis, Apoptosis and Autophagy in Acute Brain Injury: The Utilities of Biomarkers
۵. Acute, Subacute and Chronic Biomarkers for CNS Injury
۶. Biomarkers for Differential Calpain Activation in Healthy and Diseased Brains: a Systematic Review

Section B: CNS Injury Biomarkers

۷. Protein Biomarkers for Mild Traumatic Brain Injury
۸. Rehabilomics Concepts: An Overview of Genetic, Proteomic and Hormonal Biomarkers in TBI Recovery
۹. Clinical Biomarkers: Neurotherapeutics and Recovery from Traumatic Brain Injury
۱۰. Inflammatory Biomarkers of Brain Injury and Disease
۱۱. Biomarkers in Spinal Cord Injury

Section C: Other CNS Disorder Biomarkers

۱۲. miRNAas Biomarkers for Multiple Sclerosis: Quest for Identification and Treatment
۱۳. Putative Protein Biomarkers of Multiple Sclerosis
۱۴. Various Types of Multiple Sclerosis Biomarkers
۱۵. Biomarkers and Neurodegenerative Diseases: Promising Inroads Toward a Distant Goal
۱۶. Biomarkers of Apoptosis and Inflammation in Neurodegenerative Disorders
۱۷. Neurological Context of Charcot-Marie-Tooth Disease: Implication of Molecular Mechanisms and Therapeutical Approaches
۱۸. Alpha-Synuclein and 14-3-3 Proteins as Biomarkers of Neurodegenerative Diseases
۱۹. Transcrania I Magnetic Stimulation and Deep Brain Stimulation in Neuropsychiatric Disorders: New Dimension of Therapeutic Markers in Psychiatry
۲۰. Biomarkers of Nerve Regeneration in Peripheral Nerve Injuries: An Emerging Field
۲۱. Biomarkers of Drug Abuse-induced Brain Changes: Role of Microglia in Alcohol-induced Neurotoxicity