As the global population ages the impact of neurodegenerative disease.s like Alzheimer’s disease and Parkinson’s disease are significant forces in shaping human health and quality of life in the 21st century. Insights into understanding these diseases, and knowing how to treat them are major frontiers of scientific research.

Neurodegenerative Disease.s: Unifying Principles is the result of a conceptual revolution over the last decade in our understanding of neurodegenerative diseases as sharing unifying features. There is an increasing appreciation of the common biological and pathological features across seemingly varied neurodegenerative diseases that entail protein misfolding dysfunction and its consequences over time. Providing an overview of this conceptual change is the main theme for the book. Conventional approach emphasize the differences among neurodegenerative disorders, here Drs. Cummings and Pillai compile the increasingly compelling evidence that these disorders share many features and that insights in one may be rapidly translated into advances in another. The goal is to accelerate understanding by showing linkages among biological, pathological, can clinical aspects of this class of diseases.

This collection of 19, inter-related chapters, articulates and broadens our view of the unifying features that initiate and drive disease progression across a variety of neurodegenerative diseases over time. This book will serve as an outstanding sourcebook of insights from experts that have played key roles in this story.

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Contents

۱. Neurodegenerative Disease.s: Evolving Unifying Principles
۲. Neurodegenerative Disease.s as Protein Misfolding Disorders
۳. Calcium Hypothesis of Neurodegeneration: The Case of Alzheimer’s Disease and Huntington’s Disease
۴. Neuroinflammation and Neurodegenerative Diseases
۵. Prion Paradigm of Human Neurodegenerative Disease.s Caused by Protein Misfolding
۶. Neuropsychiatric Features Across Neurodegenerative Disease.s
۷. Brain Circuits: Neurodegenerative Disease.s
۸. Fluid Biomarkers Indicative of Neurodegenerative Diseases
۹. Predementia Disorders: Neurodegenerative Disorder Predecessor States as Unifying Clinical Features
۱۰. Genetics of Neurodegenerative Disease.s: Sporadic and Autosomal Dominant Forms
۱۱. An Epigenetics Perspective on Disease.s of the Central Nervous System
۱۲. Mitochondrial Changes and Bioenergetics in Neurodegenerative Diseases
۱۳. Cell Culturer iPS Cells and Neurodegenerative Diseases
۱۴. Animal Models of Neurodegenerative Disease.s
۱۵. Metal-Protein Attenuating Compounds in Neurodegenerative Disease.s
۱۶. Disease-Modifying Therapies in Neurodegenerative Disorders
۱۷. Immunotherapy for Neurodegenerative Disorders
۱۸. Clinical Trials and Drug Development in Neurodegenerative Diseases: Unifying Principles
۱۹. Conclusions on Neurodegenerative Disorders: Unifying Principles