Multiple Sclerosis: A Mechanistic View provides a unique view of the pathophysiology of multiple sclerosis (MS) and related disorders. As the only book on the market to focus on the mechanisms of MS rather than focusing on the clinical features and treatment of the disease, it describes the role of genetic and environmental factors in the pathogenesis of MS, the role of specific cells in the pathophysiology of the disease, and the pathophysiology of inflammatory and neurodegenerative disorders related to MS.

The book provides discussion of neurodegeneration and neuroregeneration, two critical emerging areas of research, as well as detailed discussion of the mechanisms of action of the approved and investigational drugs for treatment of MS and the emerging role of magnetic resonance spectroscopy (MRI) in investigations into MS.

It is the only book on the market to offer comprehensive coverage of the known mechanisms of MS and related diseases, and contains contributions from physicians and researchers who are worldwide experts in the field of study.

• Focuses on the pathophysiologic mechanisms of multiple sclerosis and the mechanisms of action in agents for the treatment of MS
• Discusses the roles of neurodegeneration and neuroregeneration in MS and related diseases
• Authored and edited by international leaders in the field of MS research

About the Author

Contents

Chapter 1. Clinical Manifestations of Multiple Sclerosis: An Overview
Chapter 2. Novel Therapies for Multiple Sclerosis: A Mechanistic View
Chapter 3. Role of B Cells in the Pathogenesis of Multiple Sclerosis: Mechanisms of Action
Chapter 4. Role of CD4+ T Cells in the Pathophysiology of Multiple Sclerosis
Chapter 5. Granulocyte-Macrophage Colony-Stimulating Factor in Central Nervous System Autoimmunity
Chapter 6. Role of Cytokine-Mediated Crosstalk between T Cells and Nonimmune Cells in the Pathophysiology of Multiple Sclerosis
Chapter 7. Vitamin D: Role in Pathogenesis of Multiple Sclerosis
Chapter 8. Role of Genetic Factors in Pathophysiology of Multiple Sclerosis
Chapter 9. Neuropathology of Multiple Sclerosis
Chapter 10. Pathophysiology of Acute Disseminated Encephalomyelitis
Chapter 11. Pathophysiology of Experimental Autoimmune Encephalomyelitis
Chapter 12. Pathophysiology of Optic Neuritis
Chapter 13. Neurodegeneration and Remyelination in Multiple Sclerosis
Chapter 14. Mechanisms of Action of Glatiramer Acetate in the Treatment of Multiple Sclerosis
Chapter 15. Mechanism of Action of Interferon Beta in Treatment of Multiple Sclerosis
Chapter 16. Mechanisms of Blood–Brain Barrier Disintegration in the Pathophysiology of Multiple Sclerosis
Chapter 17. Mechanisms and Potentials of Stem Cells in the Treatment of Multiple Sclerosis: The Unpaved Path
Chapter 18. Role of Neuroimaging in Multiple Sclerosis
Chapter 19. Pathophysiology of Lymphatic Drainage of the Central Nervous System: Implications for the Pathophysiology of Multiple Sclerosis