Authored by the world’s foremost stroke experts, this classic text brings you fully up to date with current research findings and management approaches for cerebrovascular disease. Stroke: Pathophysiology, Diagnosis, and Management, 7th Edition, covers every aspect of this fast-moving field, and is an ideal resource for stroke specialists, general neurologists, and other medical professionals with an interest in stroke. You’ll find expert clinical guidance, comprehensive pathophysiology coverage, data from recent trials, advances in diagnostic tests, full-color CT images, pathology slides, and much more, for a complete picture of today’s stroke medicine.

• Helps you recognize the clinical manifestations of stroke, use the latest laboratory and imaging studies to arrive at a diagnosis, and generate an effective medical and surgical treatment plan.
• Keeps you abreast of the overwhelming volume of studies and guidelines in this dynamic field, providing clear summaries and practical evaluations of all relevant data.
• Contains updates throughout, including the latest clinical trials (thrombectomy, DAWN, DEFUSE), genetics research, prevention research, new therapies, and the new guidelines from the ASA.
• Includes new slides for lectures, covering basic science, case studies, and interventional treatment overviews.
• Features a Key Points summary at the beginning of each chapter so you can quickly find important information.
• Provides abundant full-color CT images and pathology slides that help you make efficient and accurate diagnoses.

Review

Comprehensive, authoritative coverage of stroke for specialists and generalists alike

Contents

۱. Cerebral Vascular Biology in Health and Disease
۲. Mechanisms of Thrombosis and Thrombolysis
۳. Cerebral Blood Flow and Metabolism: Regulation and Pathophysiology in Cerebrovascular Disease
۴. Histopathology of Brain Tissue Response to Stroke and Injury
۵. Molecular and Cellular Mechanisms of Ischemia-Induced Neuronal Death
۶. Intracellular Signaling: Mediators and Protective Responses
۷. The Neurovascular Unit and Responses to Ischemia
۸. Mechanisms of Damage After Cerebral Hemorrhage
۹. White Matter Pathophysiology
۱۰. Cerebral Ischemia and Inflammation
۱۱. Mechanisms of Plasticity, Remodeling and Recovery
۱۲. Genetics and Vascular Biology of Brain Vascular Malformations
۱۳. Gliovascular Mechanisms and White Matter Injury in Vascular Cognitive Impairment and Dementia
۱۴. Global Burden of Stroke
۱۵. Stroke Disparities
۱۶. Risk Factors and Prevention
۱۷. Prognosis after Stroke
۱۸. Vascular Dementia and Cognitive Impairment
۱۹. Genetic Basis of Stroke Occurrence, Prevention and Outcome
۲۰. Classification of Ischemic Stroke
۲۱. Clinical Scales to Assess Patients with Stroke
۲۲. Carotid Artery Disease
۲۳. Anterior Cerebral Artery Disease
۲۴. Middle Cerebral Artery Disease
۲۵. Posterior Cerebral Artery Disease
۲۶. Vertebrobasilar Disease
۲۷. Lacunar Syndromes, Lacunar Infarcts, and Cerebral Small-Vessel Disease
۲۸. Intracerebral Hemorrhage
۲۹. Aneurysmal Subarachnoid Hemorrhage
۳۰. Arteriovenous Malformations and Other Vascular Anomalies
۳۱. Stroke and Other Vascular Syndromes of the Spinal Cord
۳۲. Cardiac Diseases
۳۳. Atherosclerotic Disease of the Proximal Aorta
۳۴. Stroke Related to Surgery and Other Procedures
۳۵. Arterial Dissection, Fibromuscular Dysplasia, and Carotid Web
۳۶. Inflammatory and Infectious Vasculopathies
۳۷. Reversible Cerebral Vasoconstriction Syndromes
۳۸. Posterior Reversible Encephalopathy Syndrome
۳۹. Stroke and Substance Abuse
۴۰. Moyamoya Disease
۴۱. Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy
۴۲. Hematologic Disorders and Stroke
۴۳. Migraine and Stroke
۴۴. Cryptogenic Stroke
۴۵. Cerebral Venous Thrombosis
۴۶. Ultrasonography
۴۷. Computed Tomography-Based Evaluation of Cerebrovascular Disease
۴۸. Magnetic Resonance Imaging of Cerebrovascular Diseases
۴۹. Cerebral Angiography
۵۰. OMICs in Stroke: Insight into stroke through epigenomics, transcriptomics, proteomics, lipidomics, and metabolomics
۵۱. Stroke Systems of Care and Impact on Acute Stroke Treatment
۵۲. Prehospital and Emergency Department Care of the Patient with Acute Stroke
۵۳. Intravenous Thrombolysis
۵۴. Antithrombotic Therapy for Treatment of Acute Ischemic Stroke
۵۵. General Stroke Management and Stroke Units
۵۶. Critical Care of the Patient with Acute Stroke,
۵۷. Pharmacologic Modification of Acute Cerebral Ischemia
۵۸. Treatment of “Other” Stroke Etiologies
۵۹. Medical Therapy of Intracerebral and Intraventricular Hemorrhage
۶۰. Rehabilitation and Recovery of the Patient with Stroke
۶۱. Interventions to Improve Recovery after Stroke
۶۲. Enhancing Stroke Recovery with Cellular Therapies
۶۳. Antiplatelet Therapy for Secondary Prevention of Stroke
۶۴. Secondary Prevention of Cardioembolic Stroke
۶۵. Design of Stroke-Related Clinical Trials
۶۶. Endovascular Therapy of Extracranial and Intracranial Occlusive Disease
۶۷. Endovascular Treatment of Acute Ischemic Stroke
۶۸. Endovascular Treatment of Intracranial Aneurysms
۶۹. Interventional Therapy of Brain and Spinal Arteriovenous Malformations
۷۰. Dural Arteriovenous Malformations
۷۱. Surgery of Anterior and Posterior Aneurysms
۷۲. Surgery for Intracerebral Hemorrhage
۷۳. Management of Intraventricular Hemorrhage
۷۴. Surgical Management of Cranial and Spinal Arteriovenous Malformations
۷۵. Surgical Management of Cavernous Malformations and Venous Anomalies
۷۶. Indications for Carotid Endarterectomy in Patients with Asymptomatic and Symptomatic Carotid Stenosis
۷۷. Extracranial to Intracranial Bypass for Cerebral Ischemia
۷۸. Decompressive Craniectomy for Infarction and Hemorrhage