Focusing on the scientific basis of skin moisturization, this expanded Second Edition of Skin Moisturization explores a wide range of topics, from the biological aspects of the skin to the formulation of the active ingredients in skin moisturizers. Ideal for dermatologists, cosmetic scientists, and clinical scientists interested in the treatment of xerotic skin conditions, the text discusses the latest technology and trends in the ever-growing and expanding cosmetic industry.

Features

• Chapters that review the relevant research in a particular area by providing recent clinical findings
• An overview of clinical and consumer testing approaches and ex vivo evaluation procedures, including the evaluation methodology, and regulatory and safety aspects of skin moisturizers
• Action efficacy and formulation of various moisturizing ingredients that include emollients, humectants, ceramides and other barrier lipids, alphahydroxyacids, and enzymes

Contents

Chapter 1 The Keys to Epidermal Differentiation
Chapter 2 Lipid Organization of the Skin Barrier
Chapter 3 Untangling the Role of Keratin in Stratum Corneum
Chapter 4 The Role of Filaggrin in Skin Diseases
Chapter 5 Peptidylarginine Deiminases in Skin Biology
Chapter 6 Cornified Envelope
Chapter 7 Corneodesmosomal Proteins
Chapter 8 Kallikrein-Related Peptidases: An Emerging Family of Pivotal Players in Epidermal Desquamation and Barrier Function
Chapter 9 Aquaporins and Tight Junctions
Chapter 10 Epidermal pH
Chapter 11 The Molecular Aspects of Dry, Flaky Skin Conditions
Chapter 12 Xerotic Skin Conditions and SC Properties: Diabetic Dry Skin
Chapter 13 Skin Barrier Dysfunction in Atopic Dermatitis
Chapter 14 Self-Perceived Sensitive Skin: A New Understanding Based on Epidermal Nerves
Chapter 15 Psychological Stress and Skin
Chapter 16 Stratum Corneum Biomechanics
Chapter 17 Glycerol as Humectant in Cosmetic Formulations
Chapter 18 Lanolin and the Skin
Chapter 19 Moisturization Mechanisms: Internal Occlusion by Orthorhombic Lipid Phase Stabilizers— A Novel Mechanism of Action of Skin Moisturization
Chapter 20 The Effects of Niacinamide-Containing Moisturizers
Chapter 21 Urea As a Moisturizing and Barrier-Enhancing Ingredient
Chapter 22 Hydroxyacids and Salicylic Acid
Chapter 23 Stratum Corneum Serine Proteases and Effect of Inhibitors on Dry Skin
Chapter 24 Cannabinoids and Pruritus
Chapter 25 Microdermabrasion: Clinical, Histologic,, and Molecular Effects
Chapter 26 Cosmetic Benefits Derived from the Topical Application of Acid Proteases
Chapter 27 Skin Moisturization by Dermonutrition
Chapter 28 Capacitance Imaging for Viewing and Measuring Skin Surface Hydration
Chapter 29 Vibrational Imaging and Microspectroscopy of Natural Moisturizing Factor Concentration in Human Corneocytes
Chapter 30 Measuring Water Gradients Using Confocal Raman Microspectroscopy
Chapter 31 New Developments in Skin Barrier Measurements