Current, comprehensive, and evidence-based Braunwald’s Heart Disease remains the most trusted reference in the field and the leading source of reliable cardiology information for practitioners and trainees worldwide. The fully updated 12th Edition continues the tradition of excellence with dependable, state-of-the-art coverage of new drugs, new guidelines, more powerful imaging modalities, and recent developments in precision medicine that continue to change and advance the practice of cardiovascular medicine. Written and edited by global experts in the field, this award-winning text is an unparalleled multimedia reference for every aspect of this complex and fast-changing area.

• • Offers balanced, dependable content on rapidly changing clinical science, clinical and translational research, and evidence-based medicine.

• • Includes ۷۶ new contributing authors and ۱۴ new chapters that cover Artificial intelligence in Cardiovascular Medicine; Wearables; Influenza, Pandemics, COVID-19, and Cardiovascular Disease; Tobacco and Nicotine Products in Cardiovascular Disease; Cardiac Amyloidosis; Impact of the Environment on Cardiovascular Health, and more.

• Features a new introductory chapter Cardiovascular Disease: Past, Present, and Future by Eugene Braunwald, MD, offering his unique, visionary approach to the field of cardiology. Dr. Braunwald also curates the extensive, bimonthly online updates that include “Hot Off the Press” (with links to Practice Update) and “Late-Breaking Clinical Trials”.
• • Provides cutting-edge coverage of key topics such as proteomics and metabolomics, TAVR, diabetocardiology, and cardio-oncology.

• • Contains ۱,۸۵۰ high-quality illustrations, radiographic images, algorithms, and charts, and provides access to ۲۱۵ videos called out with icons in the print version.

• • Highlights the latest AHA, ACC, and ESC guidelines to clearly summarize diagnostic criteria and clinical implications.

• Provides tightly edited, focused content for quick, dependable reference. Flexible format options include either one or two volumes in print, as well as a searchable eBook with ongoing updates.

Contents

۱ Global Burden and Epidemiology of Cardiovascular Disease
۲ Global Burden and Epidemiology of Cardiovascular Disease
۳ Impact of the Environment on Cardiovascular Health
۴ Clinical Trials in Cardiovascular Medicine
۵ Clinical Decision Making in Cardiology
۶ Impact of Healthcare Policy on Quality and Outcomes of Cardiovascular Disease
۷ Applications of Genetics to Cardiovascular Medicine
۸ Proteomics and Metabolomics in Cardiovascular Medicine
۹ Principles of Drug Therapeutics, Pharmacogenomics, and Biologics
۱۰ Biomarkers and Use in Precision Medicine
۱۱ Artificial Intelligence in Cardiovascular Medicine
۱۲ Wearable Devices in Cardiovascular Medicine
۱۳ History and Physical Examination: An Evidence-Based Approach
۱۴ Electrocardiography
۱۵ Exercise Physiology and Testing
۱۶ Echocardiography
۱۷ Chest Radiography in Cardiovascular Disease
۱۸ Nuclear Cardiology
۱۹ Cardiovascular Magnetic Resonance Imaging
۲۰ Cardiac Computed Tomography
۲۱ Coronary Angiography and Intravascular Imaging
۲۲ Invasive Cardiac Hemodynamics
۲۳ Anesthesia and Noncardiac Surgery in Patients with Heart Disease
۲۴ The Vascular Biology of Atherosclerosis
۲۵ Primary Prevention of Cardiovascular Disease
۲۶ Systemic Hypertension: Mechanisms, Diagnosis, and Treatment
۲۷ Lipoprotein Disorders and Cardiovascular Disease
۲۸ Tobacco and Nicotine Products in Cardiovascular Disease
۲۹ Nutrition and Cardiovascular and Metabolic Diseases
۳۰ Obesity: Medical and Surgical Management
۳۱ Diabetes and the Cardiovascular System
۳۲ Exercise and Sports Cardiology
۳۳ Comprehensive Cardiac Rehabilitation
۳۴ Integrative Approaches to the Management of Patients with Heart Disease
۳۵ Approach to the Patient with Chest Pain
۳۶ Coronary Blood Flow and Myocardial Ischemia
۳۷ ST-Elevation Myocardial Infarction: Pathophysiology and Clinical Evolution
۳۸ ST-Elevation Myocardial Infarction: Management
۳۹ Non-ST Elevation Acute Coronary Syndromes
۴۰ Stable Ischemic Heart Disease
۴۱ Percutaneous Coronary Intervention
۴۲ Diseases of the Aorta
۴۳ Peripheral Artery Diseases
۴۴ Treatment of Noncoronary Obstructive Vascular Disease
۴۵ Prevention and Management of Ischemic Stroke
۴۶ Mechanisms of Cardiac Contraction and Relaxation
۴۷ Pathophysiology of Heart Failure
۴۸ Approach to the Patient With Heart Failure
۴۹ Diagnosis and Management of Acute Heart Failure
۵۰ Management of Heart Failure Patients With Reduced Ejection Fraction
۵۱ Heart Failure with a Preserved Ejection Fraction
۵۲ The Dilated, Restrictive, and Infiltrative Cardiomyopathies
۵۳ Cardiac Amyloidosis
۵۴ Hypertrophic Cardiomyopathy
۵۵ Myocarditis
۵۶ Cardio-Oncology: Managing Cardiotoxic Effects of Cancer Therapies
۵۷ Cardio-Oncology: Approach to the Patient
۵۸ Devices for Monitoring and Managing Heart Failure
۵۹ Mechanical Circulatory Support
۶۰ Cardiac Transplantation
۶۱ Approach to the Patient with Cardiac Arrhythmias
۶۲ Mechanisms of Cardiac Arrhythmias
۶۳ Inheritable Cardiac Arrhythmias
۶۴ Pharmacologic and Non-Pharmacologic Therapy of Cardiac Arrhythmias
۶۵ Supraventricular Arrhythmias
۶۶ Atrial Fibrillation: Clinical Features, Mechanisms, and Management
۶۷ Ventricular Arrhythmias
۶۸ Bradyarrhythmias and Atrioventricular Block
۶۹ Pacemakers and Implantable Cardioverter-Defibrillators
۷۰ Cardiac Arrest and Sudden Cardiac Death
۷۱ Hypotension and Syncope
۷۲ Aortic Stenosis
۷۳ Aortic Regurgitation
۷۴ Transcatheter Aortic Valve Replacement
۷۵ Mitral Stenosis
۷۶ Mitral Regurgitation
۷۷ Tricuspid, Pulmonic, and Multivalvular Disease
۷۸ Transcatheter Therapies for Mitral and Tricuspid Valve Disease
۷۹ Prosthetic Heart Valves
۸۰ Cardiovascular Infections
۸۱ Rheumatic Fever
۸۲ Congenital Heart Disease in Adolescents and Adults
۸۳ Catheter-Based Treatment of Congenital Heart Disease
۸۴ Cardiomyopathies Induced by Drugs or Toxins
۸۵ Cardiovascular Abnormalities in HIV-Infected Individuals
۸۶ Pericardial Diseases
۸۷ Pulmonary Embolism
۸۸ Pulmonary Hypertension
۸۹ Sleep-Disordered Breathing and Cardiac Disease
۹۰ Cardiovascular Disease in the Older Patient
۹۱ Cardiovascular Disease in Women
۹۲ Pregnancy and Heart Disease
۹۳ Heart Disease in Racially and Ethnically Diverse Populations
۹۴ Influenza, Pandemics, COVID-19, and Cardiovascular Disease
۹۵ Hemostasis, Thrombosis, Fibrinolysis, and Cardiovascular Disease
۹۶ Endocrine Disorders and Cardiovascular Disease
۹۷ Rheumatic Diseases and the Cardiovascular System
۹۸ Tumors Affecting the Cardiovascular System
۹۹ Psychiatric and Behavioral Aspects of Cardiovascular Disease
۱۰۰ Neuromuscular Disorders and Cardiovascular Disease
۱۰۱ Interface Between Renal Disease and Cardiovascular Illness
۱۰۲ Cardiovascular Manifestations of Autonomic Disorders