An internationally recognized team of editors and contributors present an authoritative, state-of-the-art reference on nuclear medicine and its clinical applications. They focus on helping the reader to solve the challenges encountered in day-to-day practice, including image interpretation, image optimization techniques, and pitfalls in image acquisition and interpretation. Over 4,400 illustrations, 803 in full color, comprise a comprehensive visual guide to interpretation. This new edition also incorporates three brand-new, full-color atlases―PET and PET/CT, SPECT and SPECT/CT, and a PET brain atlas―as well as many new full-color images (more than 800 in all)!

Completely revised and thoroughly updated throughout, the 3rd Edition encompasses of all of the latest advances in the diagnostic and therapeutic modalities available for cancer, heart disease, neurologic disorders, and trauma as well as other diseases, both common and rare.

• Features over 4,400 high quality images depicting a full range of both common and rare diseases and abnormalities.
• Emphasizes how to perform and interpret a test rather than the technical aspects of the procedure, and focuses on how to solve the diagnostic problems that occur in day-to-day practice.
• Addresses practical considerations such as image interpretation, image optimization techniques, and pitfalls in image acquisition, and interpretation.
• Offers state-of-the art global perspectives from an international team of editors and authors.

• Provides completely revised and thoroughly up-to-date coverage in every chapter.
• Introduces a new co-editor―Dr Sam Gambhir, who provides new perspectives on the field’s hottest developments.
• Presents expanded coverage of tumor diagnosis and therapy · cardiac nuclear imaging · and radionuclide imaging of neurologic and psychiatric disorders.
• Features brand-new chapters on lymphoma therapy · PET imaging · sentinel lymph node biopsy · gated SPECT · multi-modality imaging · molecular imaging · drug discovery · cost/benefit analysis · and bone density.
• Incorporates full-color images throughout the text.

Review

Contents

۱ Tumor-seeking radiopharmaceuticals: nature and mechanisms
۲ Radionuclide imaging of hepatic tumors
۳ PET in lymphoma and malignant melanoma
۴ Parathyroid imaging
۵ Adrenocortical scintigraphy
۶ Gallium scintigraphy in tumor diagnosis and management
۷ Thallium-201 chloride: a tumor imaging agent
۸ MIBG in the diagnosis of neuroendocrine tumors
۹ Peptide receptor scintigraphy in oncology
۱۰ The diagnostic role of radiolabeled antibodies in cancer
۱۱ Cancer cell biology basis for nuclear oncology
۱۲ Differentiated thyroid carcinoma
۱۳ Medullary thyroid cancer
۱۴ Breast scintigraphy
۱۵ Pediatric tumors
۱۶ Functional analysis of cancer therapy effects in other organs
۱۷ The use of intraoperative probes in surgical oncology
۱۸ The sentinel lymph node in surgical oncology
۱۹ FDG PET Imaging of Head and Neck Cancer
۲۰ External Beam Radiotherapy Treatment Planning with PET
۲۱ PET in aerodigestive tumors
۲۲ PET in gynecological tumors (breast, cervical and ovarian)
۲۳ Nuclear medicine imaging in pediatric oncology
۲۴ Positron Emission Tomography (PET) in genitourinary tumors: prostate, bladder, testicular and renal cancer
۲۵ Future clinical applications of PET (amino acid and nucleoside imaging)
۲۶ PET imaging of brain tumors
۲۷ Principles of radionuclide therapy
۲۸ Dosimetric and radiobiological considerations: The MIRD concept
۲۹ Dosimetric and radiobiological considerations: Patient-individual dosimetry
۳۰ Radioiodine therapy of the thyroid: Treatment of benign thyroid diseases
۳۱ Radioiodine therapy of the thyroid: Treatment of thyroid malignancies
۳۲ Phosphorus-32 therapy in myeloproliferative disorders
۳۳ Palliation of bone pain
۳۴ Radioimmunotherapy of hematologic neoplasms
۳۵ Radioimmunotherapy of solid tumors
۳۶ MIBG therapy
۳۷ Receptor-targeted radiopeptide therapy
۳۸ Use of radiolipiodol in the treatment of hepatic tumours
۳۹ Alternative approaches to targeting therapy
۴۰ New developments: Nuclear gene therapy
۴۱ Atlas 1: PET and PET/CT
۴۲ Atlas 2: SPET and SPET/CT
۴۳ Bone scintigraphy: the procedure and interpretation
۴۴ Evaluation of primary bone tumors
۴۵ The evaluation of malignancy: metastatic bone disease
۴۶ Assessment of infection
۴۷ Radionuclide assessment of the painful joint prosthesis
۴۸ Vascular manifestations
۴۹ Bone scintigraphy in trauma
۵۰ Bone scintigraphy in sports medicine
۵۱ Growth and metabolic disorders
۵۲ Arthritis: current status of scintigraphy and future trends
۵۳ Radiation synovectomy
۵۴ Salivary gland disorders
۵۵ Esophageal function (transport and motility)
۵۶ Gastric motility
۵۷ Intestines: evaluation of absorption
۵۸ Studies of small bowel and colonic transit
۵۹ Hepatobiliary function: biliary kinetics
۶۰ Scintigraphic measurement of hepatic function
۶۱ Nuclear cardiology and cardiac transplantation
۶۲ Cardiovascular conditions: venous thrombosis
۶۳ Pulmonary embolism
۶۴ Non-embolic disease of the lungs
۶۵ Gastrointestinal bleeding
۶۶ Cholescintigraphy
۶۷ Neonatal hyperbilirubinemia
۶۸ Nuclear medicine in acute care of neurological patients
۶۹ Radiolabeled agents for the localization of infection and inflammation
۷۰ Undiagnosed fever
۷۱ Inflammatory bowel disease
۷۲ Nuclear imaging in cardiovascular infection and cardiac transplant rejection
۷۳ The immunocompromised patient
۷۴ Radiopharmaceuticals for the study of the heart
۷۵ Radionuclide ventriculography and the assessment of impaired ventricular function
۷۶ Infarct avid imaging and myocardial perfusion scintigraphy techniques using single photon radiotracers
۷۷ Cardiac positron emission tomography
۷۸ Cardiac stress
۷۹ The detection of coronary artery disease
۸۰ Assessment of prognosis in patients with known or suspected coronary artery disease
۸۱ Assessment after myocardial revascularization
۸۲ Assessment of myocardial viability in dysfunctional myocardium
۸۳ Myocardial infarction: the assessment of thrombolysis
۸۴ Congenital heart disease
۸۵ Single-photon imaging of myocardial metabolism: the role of iodine 123 fatty acids and fluorine-18 deoxyglucose
۸۶ Clinical applications of PET
۸۷ Myocardial innervation: imaging and quantification
۸۸ Nuclear medicine techniques in the assessment of human thrombosis and atheroma
۸۹ The blood-brain barrier
۹۰ Lipophilic tracers: the amines
۹۱ Lipophilic tracers for the study of regional cerebral blood flow
۹۲ Ligands for neuroreceptor imaging by positron or single photon emission tomography
۹۳ PET tracers for brain scanning
۹۴ Neuroactivation
۹۵ Image analysis in brain SPECT and PET
۹۶ SPECT brain imaging in cerebrovascular disease
۹۷ Nuclear medicine in the management of a patient with epilepsy
۹۸ Nuclear medicine and the management of patients with Parkinson’s movement disorders
۹۹ Anxiety disorders and affective disorders
۱۰۰ Addictions
۱۰۱ The management of patients with schizophrenia
۱۰۲ PET and SPECT imaging in evaluating Alzheimer’s disease and related dementias
۱۰۳ Nuclear medicine and drug studies in the brain
۱۰۴ Cerebrospinal fluid physiology, clearance flow studies and cerebrospinal fluid shunt studies
۱۰۵ Atlas 3: PET brain atlas
۱۰۶ Overview of renal nuclear medicine
۱۰۷ Radiopharmaceuticals: their intrarenal handling and localization
۱۰۸ Dynamic static renal imaging
۱۰۹ Quantitative evaluation of clearance
۱۱۰ Measurement and interpretation of renal transit times
۱۱۱ The role of PET in renal nuclear medicine
۱۱۲ Renal infection
۱۱۳ Pediatric aspects of radionuclides in nephrourology
۱۱۴ Nuclear medicine in the clinical diagnosis and treatment of obstructive uropathy
۱۱۵ Vascular disorders, with emphasis on hypertension
۱۱۶ Renal failure
۱۱۷ Space-occupying lesions and trauma
۱۱۸ Renal transplant evaluation
۱۱۹ The genital tract
۱۲۰ Fundamental molecular/cell biology
۱۲۱ Radioisotope production
۱۲۲ Radiochemistry
۱۲۳ Radiopharmacy
۱۲۴ Basic physics and detection of radiation
۱۲۵ Nuclear medicine imaging instrumentation
۱۲۶ Nuclear medicine computers: Basic principles
۱۲۷ Nuclear medicine computers: Applications
۱۲۸ Single photon emission computed tomography (SPECT)
۱۲۹ Positron emission tomography (PET)
۱۳۰ Primer on molecular imaging
۱۳۱ Radiation protection and dosimetry in clinical practice
۱۳۲ Clinical decision making: an introductory, quantitative approach to diagnostic investigations
۱۳۳ ecision analysis fundamentals