Basic Clinical Radiobiology is a concise but comprehensive textbook setting out the essentials of the science and clinical application of radiobiology for those seeking accreditation in radiation oncology, clinical radiation physics, and radiation technology.

Fully revised and updated to keep abreast of current developments in radiation biology and radiation oncology, this fifth edition continues to present in an interesting way the biological basis of radiation therapy, discussing the basic principles and significant developments that underlie the latest attempts to improve the radiotherapeutic management of cancer.

This new edition is highly illustrated with attractive 2-colour presentation and now includes new chapters on stem cells, tissue response and the convergence of radiotherapy, radiobiology, and physics. It will be invaluable for FRCR (clinical oncology) and equivalent candidates, SpRs (and equivalent) in radiation oncology, practicing radiation oncologists and radiotherapists, as well as radiobiologists and radiotherapy physicists.

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Contents

۱. Introduction: The significance of radiobiology and radiotherapy for cancer treatment
۲. Irradiation-induced damage and the DNA damage response
۳. Cell death after irradiation: How, when and why cells die
۴. Quantifying cell kill and cell survival
۵. Radiation dose-response relationships
۶. Linear energy transfer and relative biological effectiveness
۷. Physics of radiation therapy for the radiobiologist
۸. Tumour growth and response to radiation
۹. Fractionation: The linear-quadratic approach
۱۰. The linear-quadratic approach in clinical practice
۱۱. Modified fractionation
۱۲. Time factors in normal tissue responses to irradiation
۱۳. The dose-rate effect
۱۴. Pathogenesis of normal tissue side effects
۱۵. Stem cells in radiotherapy
۱۶. Normal tissue tolerance and the effect of dose inhomogeneities
۱۷. The oxygen effect and therapeutic approaches to tumour hypoxia
۱۸. The tumour microenvironment and cellular hypoxia responses
۱۹. Combined radiotherapy and chemotherapy
۲۰. Molecular targeted agents for enhancing tumour response
۲۱. Biological individualisation of radiotherapy
۲۲. Molecular image guided radiotherapy
۲۳. Retreatment tolerance of normal tissues
۲۴. Biological response modification of normal tissue reactions: Basic principles and pitfalls
۲۵. Hadron therapy: The clinical aspects
۲۶. Tissue response models
۲۷. Second cancers after radiotherapy